STALEVO (carbidopa/levodopa/entacapone) tablets are indicated for patients with Parkinson’s Disease (PD). STALEVO is a medicine that can be used instead of carbidopa/levodopa and Comtan® (entacapone) by patients taking those medicines as separate tablets. Depending on levodopa dose and side effects, STALEVO can also be used to replace carbidopa/levodopa when the benefits of levodopa are wearing off. Please ask your healthcare professional if Stalevo is appropriate for you.

STALEVO is supplied as tablets in three strengths: STALEVO 50 containing 12.5mg carbidopa, 50mg levodopa and 200mg entacapone; STALEVO 100 containing 25mg carbidopa, 100mg levodopa and 200mg entacapone; STALEVO 150 containing 37.5mg carbidopa, 150mg levodopa and 200mg entacapone.

The most common side effects of STALEVO are unwanted or uncontrollable movements (known as dyskinesia), nausea, diarrhea, excessive muscle movements (known as hyperkinesia), harmless discoloration of urine, sweat and/or saliva, diminished or slow movements (known as hypokinesia), abdominal pain, dizziness, constipation, fatigue, pain, and hallucinations. Some of the more serious side effects may include severe diarrhea, severe dyskinesia, hallucinations, other mental disturbances, orthostatic hypotension (low blood pressure), rhabdomyolysis (a muscle disease) and symptoms resembling neuroleptic malignant syndrome (a condition characterized by fever and muscle stiffness).

Tell your healthcare professional if you have bothersome side effects. He or she can make adjustments that may reduce these effects. You should not quickly lower your STALEVO dose, or suddenly stop it altogether.

Drugs broken down by the COMT enzyme (e.g. isoproterenol, epinephrine) should be used with caution when taking STALEVO. If you take a nonselective monoamine oxidase (MAO) inhibitor, you should not take STALEVO. STALEVO should not be taken with selegiline at doses higher than 10mg/day.

Because STALEVO contains entacapone, it should not be taken together with Comtan.

Be careful using STALEVO if you have severe heart or lung disease, asthma, renal, hepatic, or endocrine disease, or a history of heart attacks or ulcers. Do not take STALEVO if you have glaucoma, melanoma, or other related medical disorders. Before you take STALEVO, talk to your doctor about any health problems you might have.

For more information about STALEVO, read the full prescribing information. The prescribing information will explain how STALEVO will act in your body, possible side effects, drug interactions, and precautions for certain patients.